Gene information
Official symbol ADRA2C
Official full name adrenoceptor alpha 2C
Gene type protein-coding gene
Chromosome4p16.3
Alias symbolADRARL2
Previous symbolADRA2L2; ADRA2RL2
Gene familyAdrenoceptors
Resources
Entrez Gene 152
HGNC HGNC:283
Ensembl ENSG00000184160
Vega OTTHUMG00000159830
UCSC uc003ghm.4
GO terms: 32 records
GO Description Category LogP Number of genes Detail
GO:0003013 circulatory system process GO Biological Processes -65.2875605 130 More
GO:0006937 regulation of muscle contraction GO Biological Processes -20.8046481 43 More
GO:0006940 regulation of smooth muscle contraction GO Biological Processes -12.9613663 21 More
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway GO Biological Processes -9.16710904 33 More
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO Biological Processes -6.95524830 22 More
GO:0008015 blood circulation GO Biological Processes -65.7270163 119 More
GO:0010700 negative regulation of norepinephrine secretion GO Biological Processes -4.82387082 4 More
GO:0031690 adrenergic receptor binding GO Molecular Functions -4.18483678 6 More
GO:0032147 activation of protein kinase activity GO Biological Processes -11.6086663 28 More
GO:0032148 activation of protein kinase B activity GO Biological Processes -8.71311579 12 More
GO:0033604 negative regulation of catecholamine secretion GO Biological Processes -3.89921208 5 More
GO:0033674 positive regulation of kinase activity GO Biological Processes -29.8538991 87 More
GO:0042803 protein homodimerization activity GO Molecular Functions -14.2815375 77 More
GO:0043408 regulation of MAPK cascade GO Biological Processes -57.2547066 142 More
GO:0043410 positive regulation of MAPK cascade GO Biological Processes -49.4744054 112 More
GO:0043549 regulation of kinase activity GO Biological Processes -36.8507249 123 More
GO:0044057 regulation of system process GO Biological Processes -61.6610386 136 More
GO:0045666 positive regulation of neuron differentiation GO Biological Processes -4.58725293 14 More
GO:0045859 regulation of protein kinase activity GO Biological Processes -34.3615088 109 More
GO:0050433 regulation of catecholamine secretion GO Biological Processes -6.37680507 13 More
GO:0051046 regulation of secretion GO Biological Processes -54.0079540 130 More
GO:0051048 negative regulation of secretion GO Biological Processes -20.2278199 42 More
GO:0051051 negative regulation of transport GO Biological Processes -46.8709407 107 More
GO:0051347 positive regulation of transferase activity GO Biological Processes -26.6059528 90 More
GO:0051952 regulation of amine transport GO Biological Processes -10.5179624 22 More
GO:0071875 adrenergic receptor signaling pathway GO Biological Processes -8.98205881 11 More
GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway GO Biological Processes -9.78130162 11 More
GO:0090257 regulation of muscle system process GO Biological Processes -33.9441291 67 More
GO:1903522 regulation of blood circulation GO Biological Processes -44.9821911 79 More
GO:1903530 regulation of secretion by cell GO Biological Processes -45.6472055 114 More
GO:1903531 negative regulation of secretion by cell GO Biological Processes -17.4034654 36 More
GO:2000273 positive regulation of signaling receptor activity GO Biological Processes -8.61037442 14 More
KEGG pathways: 1 record
KEGG Description Category LogP Number of genes Detail
hsa04080 Neuroactive ligand-receptor interaction KEGG Pathway -22.6219922 65 More
Drug-Gene interaction
view
Related drugs: 62 records
Drug name Interaction type Source PMID View
alseroxylon antagonist ChemblInteractions view
amezinium TTD view
amosulalol TTD view
apraclonidine hydrochloride agonist ChemblInteractions view
asenapine antagonist TdgClinicalTrial 18308814 view
bethanidine TdgClinicalTrialTEND view
brimonidine agonist TENDPharmGKBTTD 11606316126706991461063716757535 view
brimonidine tartrate agonist ChemblInteractions view
bucindolol PharmGKB 23071495 view
clonidine agonist TdgClinicalTrialChemblInteractionsPharmGKB 2083365811082457 view
clonidine hydrochloride agonist ChemblInteractions view
cyclobenzaprine TTD view
debrisoquin TdgClinicalTrialTEND view
dexmedetomidine hydrochloride agonist ChemblInteractions view
dihydroergocristine TTD view
dipivefrin hydrochloride agonist ChemblInteractions view
dopamine PharmGKB view
droxidopa agonist ChemblInteractions 21173850186802048590979 view
epinephrine agonist ChemblInteractionsPharmGKB 1346768 view
epinephrine bitartrate agonist ChemblInteractions view
ergoloid mesylates antagonist ChemblInteractions view
esmirtazapine maleate antagonist ChemblInteractions view
fadolmidine TTD view
fadolmidine hydrochloride agonist ChemblInteractions view
fenoldopam antagonist TEND 76707371713928417016423 view
fipamezole TdgClinicalTrial view
guanabenz acetate agonist ChemblInteractions view
guanfacine hydrochloride agonist ChemblInteractions view
hydroxyamphetamine hydrobromide agonist ChemblInteractions view
iloperidone antagonist TdgClinicalTrial view
isoproterenol PharmGKB view
labetalol hydrochloride antagonist ChemblInteractions view
levonordefrin agonist ChemblInteractions view
lofexidine agonist TdgClinicalTrialTEND view
lurasidone antagonist TdgClinicalTrial 23545936 view
medetomidine TTD view
mephentermine sulfate agonist ChemblInteractions view
methamphetamine agonist TdgClinicalTrial 955176915955613 view
methyldopa agonist ChemblInteractions view
methyldopate hydrochloride agonist ChemblInteractions view
mirtazapine antagonistbinder ChemblInteractions 157714153419539 view
moxonidine TTD view
naphazoline hydrochloride agonist ChemblInteractions view
norepinephrine agonist TdgClinicalTrialTENDPharmGKB 18064417165426819802361741012317139284170164238590979 view
norepinephrine bitartrate agonist ChemblInteractions view
olanzapine antagonist TdgClinicalTrial 17848919 view
orm-12741 TTD view
oxymetazoline hydrochloride agonist ChemblInteractions view
phenoxybenzamine hydrochloride antagonist ChemblInteractions view
phentolamine mesylate antagonist ChemblInteractions view
propylhexedrine TTD view
rauwolfia serpentina antagonist ChemblInteractions view
rilmenidine TTD view
senrebotase TdgClinicalTrial view
tetrahydrozoline TTD view
tetrahydrozoline hydrochloride agonist ChemblInteractions view
tetrasul TTD view
tizanidine agonist TdgClinicalTrial 8930173 view
tizanidine hydrochloride agonist ChemblInteractions view
tolazoline hydrochloride antagonist ChemblInteractions view
xylometazoline agonist TTD 20030735 view
yohimbine antagonist TdgClinicalTrialTENDPharmGKB 112264021617644412591093124385171211061010611634 view
Related study: 1 record
Molecular factor Omics type Application Objective MI type Reference
Chr4:3728294 hypermethylation epigenomics ischemic cardiac events[prognosis (bad)] myocardial infarction Thunders M et al. Epigenetics. 2019
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